Fig. 7

Platelet production and consumption, observed and predicted parameter values. Optimal RD and PR values from Table 1 are plotted for each of the patients in the study. Projected values for thrombocytopenias due to reduced production (at three values of HRD/RD), increased consumption with no homeostatic increase in production, and increased consumption with a compensatory increase in production rate, were interpolated as described in the text. a Population turnover rate, which at equilibrium equals platelet production rate, vs. platelet count. b Random destruction rate (RD) vs. platelet count. c RD and PR values from a and b. Error bars are standard deviations arrived at via jacknife resampling (see text)