Numerical analysis of in vivo platelet consumption data from ITP patients

Strom, Ted S.

doi:10.1186/s12878-015-0034-4

BMC Hematology

Table 1 Patient characteristics, search parameter ranges, and optimal parameter values

From: Numerical analysis of in vivo platelet consumption data from ITP patients

Patient characteristics		Search parameter ranges			Optimal parameter values and residuals (SS/n)
Patient	Platelets (x 10e9/L)	n (data points)	RD (%/h)	LL (%)	RD (%/h)	CV	LS (hr)	CV	LL (%)	CV	SD (of ln LS)	PR (K/ul/h)	SS/n
1	30	6	0–4.75	0–15.2	2.5	0.08	189	0.39	6.4	0.44	0.2	0.77	0.43
2	119	9	0–4.75	0–15.2	0.75	0.39	228	0.2	12.8	0.3	0.2	0.89	6..92
3	165	9	0–4.75	0–15.2	2	0.15	176	0.2	8.8	0.11	0.3	3.55	1.81
4	24	9	4.5–9.25	0–15.2	6.75	0.13	267	na*	4.8	0.31	0.2	1.62	8.26
5	80	9	3.5–8.25	0–15.2	5.5	0.06	215	na*	4.8	0.23	0.2	4.4	2.61
7	41	9	1.0–5.75	0–15.2	3.5	0.06	176	0.51	6.4	< 0.13**	0.1	1.44	12
8	58	8	0–4.75	15.2–30.4	2	0.43	202	0.36	23.2	0.44	0.1	1.64	42.5
11	10	5	9.5–14.75	0–15.2	12.5	0.02	267	na*	7.2	1.81	0.2	1.25	19.3
13	44	6	0–4.75	0–15.2	1.5	0.28	189	0.39	9.6	0.63	0.1	0.71	15.8
14	17	5	9.5–15.25	0–15.2	12.25	0.11	72	2.94	0	(sd < 0.06**)	0.3	2.08	7.02
17	8	9	0–4.75	0–15.2	1.75	0.2	215	0.56	10.4	1.05	0.1	0.14	36.3
18	88	7	0–4.75	0–15.2	2	0.2	150	0.77	8	0.34	0.2	1.92	3.3
20	45	9	2.5–7.25	0–15.2	5.25	0.11	228	0.4	6.4	0.42	0.2	2.36	22.1
21	143	9	0–4.75	8.8–24.0	0	(sd < 0.22**)	124	< 0.12**	11.2	0.16	0.2	1.34	5.82
22	85	8	0–4.75	0–15.2	1.25	0.32	111	0.14	5.6	0.43	0.3	1.61	1.49
23	119	9	0–4.75	15.2–30.4	0	(sd = 0.22)	124	0.09	22.4	0.07	0.3	1.2	4.03
24	20	6	0–4.75	0–15.2	2.5	0.8	33	0.66	1.6	0.42	0.3	1.04	21.4
25	39	9	2.0–6.75	0–15.2	4.5	0.09	228	0.75	4.8	0.2	0.2	1.76	8.2
27	2	9	5.5–10.25	0–15.2	8.25	0.06	176	0.73	11.2	0.18	0.1	0.17	4.77
28	22	9	0–4.75	0–15.2	2.25	0.2	254	0.35	13.6	0.25	0.1	0.5	24.4
29	34	9	2.0–6.75	0–15.2	4.5	0.23	189	0.85	6.4	0.4	0.1	1.53	18.1
30	13	6	0–4.75	0–15.2	1.75	0.24	137	0.25	6.4	1.05	0.2	0.26	6.28
32	36	5	3.0–7.75	0–15.2	7.25	0.04	72	0.53	2.4	0.27	0.1	2.63	0.38
33	238	7	0–4.75	13.6–28.8	0.25	2.56	163	0.47	20.8	0.39	0.2	2.33	10.2
34	77	6	2.0–6.75	16.8–32.0	4.5	0.27	124	0.35	24	0.23	0.1	3.49	5.51
35	37	9	0.5–5.25	0–15.2	3	0.48	137	1.02	5.6	0.36	0.3	1.17	13.4
36	32	6	4.5–9.25	0–15.2	5.75	0.15	111	0.58	6.4	0.95	0.2	1.85	5.88
37	102	6	0–4.75	11.2–26.4	3	0.58	228	0.31	17.6	0.43	0.1	3.07	49.5
38	170	7	0–4.75	17.6–32.8	0.25	1.2	150	0.07	24.8	0.05	0.1	1.45	2.81
39	21	6	3.0–7.75	0–15.2	5.25	0.35	111	1.27	12.8	0.39	0.2	1.12	27.3
40	43	6	2.5–7.25	0–15.2	5	0.35	124	na*	14.4	0.41	0.2	2.16	15.8
Normalized	191	23	0.05–1.0	na	0.5		140		na		0.2	2.12	57.3

Platelet counts were obtained at the time of the study. Patients 1,2, and 3 showed a major subsequent response to splenectomy (see text). Resolution is equal to 5 % of the search ranges shown. The “normalized” data set is pooled data from the three patients (3, 33, and 38) whose platelet counts transiently exceeded 150 K/ul in response to prednisone. CV values were obtained by “jackknife” resampling (see text). “na*” denotes cases for which one or more of the resampled or complete data sets yielded LS values at the high end of the search range. Values marked by ** were for cases in which all of the resampled data sets yielded the same optimal parameter value (see Methods)

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